Symptoms of blurred vision, cycloplegia and dry eye are transient and reversible.7. 19. Two well-known antidepressants are Zoloft (sertraline, Pfizer) and Paxil (paroxetine, GlaxoSmithKline). Boston: Butterworth-Heinemann, 1995:957- 1006. Don’t run to the drugstore for eye drops. 2008 Jan;145(1):60-73. Do not consider this brief discussion exhaustive, as many other drugs and categories may have dry eye as a side effect. Dry eyes is a common condition that occurs when your tears aren't able to provide adequate lubrication for your eyes. Cequa (cyclosporine) is a drug that is a part of the CNI Immunosuppressants class and treats dry eyes.CNI immunosuppressants are used to treat organ transplant rejection, rheumatoid arthritis, psoriasis, dry eyes… Even though Roche Pharmaceuticals pulled Accutane from the market in 2009, generic versions of the drug may still be available by prescription. 16. Recommend your patients use only one pharmacy so the pharmacist can help monitor for drug interactions. Topiramate (Topamax) is used for the treatment of seizure disorder, migraine headache, and mood … Dr. 18. Hypertensive Agents 1981;52(3):257-8. “Many doctors think erectile dysfunction drugs cause … 3. Optom Mgmt. Pharmaceuticals that can cause dry eye symptoms include certain medications used to treat hypertension such as central-acting agents and diuretics; antihistamines and decongestants, in concert with anticholinergics; hormones; certain antidepressants; pain relievers, such as ibuprofen and lortab; and dermatologic agents. His best-selling book, The People’s Pharmacy, was published in 1976 and led to a syndicated newspaper column, syndicated public radio show and web site. Hormone replacement therapy (HRT) with estrogens alone or in combination with progestins is a commonly prescribed therapy for post-menopausal women. We NEVER suggest that a patient stop taking a medication without first checking with the prescriber. If a medication contributed to your symptoms, we would like to learn about that as well. The exact cause-and-effect relationship is unknown, but may be associated with a decreased aqueous component of the precorneal tear film.9. Antidepressant & Parkinson’s Medications Any prescription medication with a nerve-inhibiting quality has the potential to cause dry eye symptoms. 5th ed. Mellaril (thioridazine, Mutual Pharmaceutical) is the best known of this class and has almost completely replaced Thorazine (chlorpromazine, GlaxoSmithKline) in the management of the condition. What’s more, treating drug-induced dry eyes with eye drops might be a little like trying to slake your thirst in the middle of the desert with an eye dropper of water. Ocular adverse effects associated with systemic medications. Thiazides or diuretics are often prescribed to treat congestive heart failure. 8. This drug class causes decreased lacrimation, which may induce dry eye complaints. Bowling is in private group practice in Tuscaloosa, Ala. Popular medicines like Zoloft (sertraline) and Paxil (paroxetine) belong to a different class of antidepressants, called selective serotonin reuptake inhibitors (SSRIs). At the end of the day, it is our responsibility to make sure that our patients know how their systemic medications could be contributing to their ocular surface disease. 6. In: GCY Chiou, ed. Pain Relievers 17. 20. Xiidra Dry Eye Drops - Prescription only. 2002 Jan;109(1):111-8. 4. These include diuretics (water pills), antihistamines, antidepressants, drugs that lower cholesterol, beta-blockers and birth control pills. 2003 Apr. A review article in the Journal of Ophthalmology (online, Aug. 27, 2012) lists many such drugs and discusses this topic in detail. Acupuncture. Physicians and pharmacists rarely mention dry eyes as a drug side effect. That is why diabetes, herpes eye infection and laser eye surgery (LASIK) may sometimes result in dry eyes. 10. There are many potential causes for seeing double or for vision that suddenly blurs. Lesher GA. Get side effect saavy. Certain classes of drugs are known to cause eye problems. Schornack JA. www.optometric.com/article.aspx?article=70708 (Accessed April 2011). JAMA. Double or blurred vision. Reproduction in whole or in part without permission is prohibited. In: Bartlett JD & Jaanus SD (eds.). Dry eye in post-menopausal women using hormone replacement therapy. Thioridazine … They need to know the brand names and generic names of the medications they are taking. Gastrointestinal Medications So may novel psychoactive substances such as synthetic opioids (Helander et al, British Journal of Dermatology, April 2017). This … In 2006, Long Island University awarded him an honorary doctorate as “one of the country's leading drug experts for the consumer.”, Eye drop preservative (benzalkonium chloride). Such drugs can cause both a dry mouth and dry eyes by interfering with glands in these organs. Widely prescribed anti-anxiety medications and tricyclic antidepressants can produce dry eye side effects. Conditions that reduce the cornea’s sensitivity reduce blinking and tear production, too. 2007;56(3):257-62. J Am Optom Assoc. Patients need to assume some responsibility here as well. Bartlett JD. 2007 Apr;5(2):75-92. Optom Clin. Diuretics. If you have found a solution, please share your success story with others. Joe Graedon is a pharmacologist who has dedicated his career to making drug information understandable to consumers. Bergmanson JP, Rios R. Adverse reaction to painkiller in hydrogel lens wearer. Santaella RM, Fraunfelder FW. Cholesterol -lowering drugs. Isotretinoin (13-cis-retinoic acid) is a form of vitamin A that reduces the amount of oil released by oil glands in the skin.15 Vitamin A and its synthetic derivatives are collectively known as retinoids and are used to treat severe recalcitrant nodular acne, acne vulgaris and severe recalcitrant psoriasis, and to induce remission of leukemia.16 Isoretinoin has been shown to be secreted in tears by the lacrimal gland and has been associated with causing meibomian gland dysfunction—producing dry eye complaints, contact lens discomfort, blepharoconjunctivitis, transient blurring of vision and acute, transient refractive changes––especially myopic shifts.17 This synthetic medication affects the overproduction of skin lipids. Clinically important ocular reactions to systemic drug therapy. Antibiotics taken orally have been known to cause dry eyes. Ibuprofen, a common OTC pain medication, can cause dry eye in addition to blurred vision, refractive changes, diplopia and color vision changes, especially when the higher dosages (up to 800mg) are prescribed.13 Darvocet-N (propoxyphene napsylate and acetometaphin, USP) reportedly decreases tear secretion.14 Lortab (hydrocodone and acetaminophen, USP) combinations can also produce a dry eye. Jaanus SD, Bartlett JD, Hiett, JA. Drug-Induced Ocular Side Effects. 14. Fatty acids. Fraunfelder FT, Fraunfelder FW. 15. Lemp MA, Baudouin C, Baum J, et al. Xiidra (Shire), like … Dry Eye Culprits of the Drug World. Boston: Butterworth Heinemann, 2001. This can cause eye strain and dry eye, which may feel worse in the evening after a long day of work. All rights reserved. Clinical Ocular Pharmacology, 3rd ed. This incredibly unpleasant condition can be caused by a number of things. 2001;27(6):588-99. Call your doctor. In this article we will discuss several categories of pharmaceuticals, each containing medications that can produce dry eye symptoms. Debra A. Schaumberg, Sc.D., O.D., M.P.H., and colleagues reported a 69% increase in dry eye symptoms in women who were taking estrogen compared to the control group.10 Additionally, the study reported that women who were taking a progesterone or progesterone combination also experienced a 29% increase in dry eye symptoms over women not on HRT. 5. In this test, blotting strips of paper are placed under … A major drug in this class is Cytoxan (cyclophosphamide, Bristol-Myers Squibb), which is also used to treat ocular cicatricial pemphigoid and primary Sjögren syndrome. Such a drip-by-drip solution is unlikely to alleviate the problem. Tears can be inadequate for many reasons. Xiidra (ZYE-druh) is another prescription eye drop for dry eye treatment. Psychiatric manifestations of lupus erythematosus systemic and Sjögren’s syndrome. Decreased meibomian gland function also impacts the production of the lipid layer of the precorneal tear film, leading to tear film instability and enhanced surface evaporation, which results in dry eye syndrome. It is estimated that between 67 to 75 million adults in the United States have … Discuss the benefits and risks with your doctor. Fortunately, there are many resources available to help us with this information. 9. Some of these procedures … No one can possibly remember all of the potential ocular adverse events associated with each medication. The newer, more site-specific (H1 selective) antihistamines like Zyrtec (cetirizine, McNeil Consumer), Clarinex (desloratadine, Merck) and Allegra (fexofenadine, Sanofi-Adventis) are less likely to cause ocular dryness, but they may affect the tear film. The drugs in this class reduce mucous and aqueous production, which cause dry eye complaints.7 Their activity may also decrease the aqueous component of the precorneal tear film. Chemotherapy Medications List of drugs associated with a side effect named as Blurred Vision and related drug information. Ophthalmic Toxicology. Jasper A. Erdem U, Ozdegirmenci O, Sobaci E, et al. 7. Ophthalmology. In general, these effects occur with OTC preparations—most commonly with Benadryl (diphenhydramine, McNeil Consumer) and Chlor-Trimeton (chlorpheniramine, Schering)—and in recent offerings, such as Claritin (loratadine, Schering). Tricyclic antidepressants—Elavil (amitriptyline, Merck), Endep (amitriptyline, Roche), Adapin (doxepin, Lotus Biochemical), Sinequan (doxepin, Pfizer)—produce many anticholinergic side effects.12 These medications are being prescribed to a broader and younger population than in the past, which means there is an increased likelihood that your patients will display dry eye side effects. Identify the ocular side effects of systemic medications. Skin Medications Medications … Dry eyes can be caused by reduced tear production or increased evaporation from the eye's surface, but doctors rarely mention dry eyes as a drug side effect. But just ask someone with dry eyes how it affects their quality of life, and you will quickly learn that this is not a minor complication. Share your own story about dry eyes below. Wearing lenses for too long during the day can make dry eye … Antidepressants Antidepressants and anti-anxiety medications also can produce dry eye symptoms. High Blood Pressure. The effect of treatment and its related side effects in patients with severe ocular cicatricial pemphigoid. Proton pump inhibitors have caused dry eye complaints, although this information does not appear in their individual package inserts. www.optometric.com/article.aspx?article=70708, Delay of Final Contact Lens Rule Requested by Congress, Conventional, Accelerated CXL Both Effective in Children, Diagnostic Tool Aids Refractive Assessment, Ray Tracing Offers Customizable LASIK Approach, Making the Diagnosis with the TFOS DEWS II. Lissamine green staining of conjunctiva and cornea in dry eye. In certain cases, this reaction may be severe and can last for months or even years. People are surprised to learn that even non-prescription medications could be contributing to their uncomfortable eyes. Rennie IG. Brand name examples include Zoloft, Paxil, Elavil, Endep and Sinequan. 13. 2007;67(1):75-93. Pharmaceuticals that can cause dry eye symptoms include certain medications used to treat hypertension such as central-acting agents and diuretics; antihistamines and decongestants, in concert with anticholinergics; hormones; certain antidepressants; pain relievers, such as ibuprofen and lortab; and dermatologic agents. 2. This report, based on observations on 25,000 post-menopausal women, showed evidence of a significant increased risk of dry eye syndrome and severity of dry eye symptoms in women taking estrogen. Michigan: Taylor and Francis, 1999:225-83. Antihistamines are combined with anticholinergics in many OTC medications, such as cold preparations, sedatives, antidiarrheals and nasal decongestants.8 These combination medications induce dry eye, along with the commonly known effects of anticholinergics, which include mydriasis and decreased papillary response to bright light.8, Hormones Recalcitrant acne please share your success story with others alleviate allergic conditions of rhinitis, uticaria dermatitis. Helander et al eye, which may feel worse in the body supplements in. Of Dermatology, April 2017 ) well-known antidepressants are Zoloft ( sertraline, Pfizer ) and Paxil ( paroxetine GlaxoSmithKline! Lemp MA, Baudouin C, Baum J, et al, Journal... Even non-prescription medications could be contributing to their uncomfortable eyes to the drugstore for eye drops and medication don t. Cornea ’ s medications Any prescription medication with a nerve-inhibiting quality has the potential ocular adverse events with! 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